Full list of publications

• Non-linear transcriptional responses to gradual modulation of transcription factor dosage. Domingo J, Minaeva M, Morris JA, Ziosi M, Sanjana NE, Lappalainen T. bioRxiv (2024).

• Next-generation forward genetic screens: uniting high-throughput perturbations with single-cell analysis. Morris JA, Sun JS, Sanjana NE. Trends in Genetics (2023).

• Large-scale causal discovery using interventional data sheds light on the regulatory network architecture of blood traits. Brown BC, Morris JA, Lappalainen T, Knowles DA. bioRxiv (2023).

• Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis. Zhou S, Sosina O, Bovijn J, Laurent L, Sharma V, Akbari P, Forgetta V, Jiang L, Kosmicki J, Banerjee N, Morris JA, Oerton E, Jones M, LeBlanc M, Idone V, Overton J, Reid J, Cantor M, Abecasis G, Goltzman D, Greenwood C, Langenberg C, Baras A, Economides A, Ferreira M, Hatsell S, Lotta L, Ohlsson C, Richards JB. Nature Genetics (2023).

• The Impact of Genomic Variation on Function (IGVF) Consortium. IGVF Consortium. arXiv (2023).

• Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens. Morris JA, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, Davis K, Ziosi M, Glinos DA, Hao S, Mimitou E, Smibert P, Roeder K, Katsevich E, Lappalainen T, Sanjana NE. Science (2023).

• Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq. Wessels H-H, Méndez-Mancilla A, Papalexi E, Mauck WM, Lu L, Morris JA, Mimitou E, Smibert P, Sanjana NE, Satija R. Nature Methods (2023).

• An effector index to predict target genes at GWAS loci. Forgetta V, Jiang L, Vulpescu NA, Hogan MS, Chen S, Morris JA, Grinek S, Benner C, Jang DK, Hoang Q, Burtt N, Flannick JA, McCarthy MI, Fauman E, Greenwood CMT, Maurano MT, Richards JB. Human Genetics (2022).

• SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis. Barry T, Wang X, Morris JA, Roeder K, Katsevich E. Genome Biology (2021).

• Childhood obesity and multiple sclerosis: A Mendelian randomization study. Harroud A, Mitchell RE, Richardson TG, Morris JA, Forgetta V, Davey Smith G, Baranzini SE, Richards JB. Multiple Sclerosis (2021).

• Automated design of CRISPR prime editors for 56,000 human pathogenic variants. Morris JA*, Rahman JA*, Guo X, Sanjana NE. iScience (2021).

• An autoimmune disease risk variant: a trans master regulatory effect mediated by IRF1 under immune stimulation? Brandt M, Kim-Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, Recinos Y, Daniloski Z, Morris JA, Hornung V, Schumacher J, Lappalainen T. PLOS Genetics (2021).

• Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Youlten SE, Kemp JP, Logan JG, Ghirardello EJ, Sergio CM, Dack MRG, Guilfoyle SE, Leitch VD, Butterfield NC, Komla-Ebri D, Chai RC, Corr AP, Smith JT, Mohanty ST, Morris JA, McDonald MM, Quinn JMW, McGlade AR, Bartonicek N, Jansson M, Hatzikotoulas K, Irving MD, Beleza-Meireles A, Rivadeneira F, Duncan E, Richards JB, Adams DJ, Lelliott CJ, Brink R, Phan TG, Eisman JA, Evans DM, Zeggini E, Baldock PA, Bassett JHD, Williams GR, Croucher PI. Nature Communications (2021).

• Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study. Forgetta V, Keller-Baruch J, Forest M, Durand A, Bhatnagar S, Kemp JP, Nethander M, Evans D, Morris JA, Kiel DP, Rivadeneira F, Johannson H, Harvey NC, Mellstrom D, Karlsson M, Cooper C, Evans DM, Clarke R, Kanis JA, Orwoll E, McCloskey EV, Ohlsson C, Ohlsson C, Pineau J, Leslie WD, Greenwood CMT, Richards JB. PLOS Medicine (2020).

• Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study. Cerani A, Zhou S, Forgetta V, Morris JA, Trajanoska K, Rivadeneira F, Larsson SC, Michaëlsson K, Richards JB. The British Medical Journal (2019).

• Effect of age at puberty on risk of multiple sclerosis: A mendelian randomization study. Harroud A, Morris JA, Forgetta F, Mitchell R, Davey Smith G, Sawcer SJ, Richards JB. Neurology (2019).

• An atlas of genetic influences on osteoporosis in humans and mice. Morris JA*, Kemp JP*, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco A-L, Vijay J, Simon M-M, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum A-T, Mannan NS, Komla-Ebri D, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar M-JG, 23andMe Research Team, Adams DoJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani E, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Adams DaJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu Y-H, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB. Nature Genetics (2019).

• Genome-wide association of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes. Gregson C, Newel F, Leo PJ, Clark GR, Paternoster L, Mhairi M, Forgetta V, Morris JA, Ge B, Bao X, Bassett JHD, Williams GR, Youlten SE, Croucher PI, Davey Smith G, Evans DM, Kemp JP, Brown MA, Tobias JH, Duncan EL. Bone (2018).

• Assessment of the genetic and clinical determinants of fracture risk: Genome-wide association and Mendelian randomization study. Trajanoska K*, Morris JA*, Oei L*, Zheng H-F*, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F; on behalf of the GEFOS/GENOMOS Consortium and the 23andMe Research Team. The British Medical Journal (2018).

• FAM210A is a Novel Determinant of Bone and Muscle Structure and Strength. Tanaka K, Xue Y, Nguyen-Yamamoto L, Morris JA, Kanazawa I, Sugimoto T, Wing SS, Richards JB, Goltzman D. Proceedings of the National Academy of Sciences (2018).

• Metabolomic Pathways to Osteoporosis in Middle-Aged Women: A Genome-Metabolome-Wide Mendelian Randomization Study. Moayyeri A, Cheung CL, Tan KC, Morris JA, Cerani A, Mohney RP, Richards JB, Hammond C, Spector TD, Menni C. Journal of Bone and Mineral Research (2018).

• Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Kemp JP*, Morris JA*, Medina-Gomez C*, Forgetta V, Warrington NM, Youlten SE, Zheng J, Gregson CL, Grundberg E, Trajanoska K, Logan JG, Pollard AS, Sparks PC, Ghirardello EJ, Allen R, Leitch VD, Butterfield NC, Komla-Ebri DSK, Adoum A-T, Curry KF, White JK, Kussy F, Greenlaw K, Xu CJ, Harvey NC, Cooper C, Adams DJ, Greenwood CMT, Maurano MT, Kaptoge S, Rivadeneira F, Tobias JH, Croucher PI, Ackert-Bicknell CL, Bassett JHD, Williams GR, Richards JB, Evans DM. Nature Genetics (2017).

• Large differences in adiponectin levels have no clear effect on multiple sclerosis risk: A Mendelian randomization study. Devorak J, Mokry LE, Morris JA, Forgetta V, Davey Smith G, Sawcer S, Richards JB. Multiple Sclerosis (2017).

• Epigenome-wide association of DNA methylation in whole blood with bone mineral density. Morris JA*, Tsai P-C*, Joehanes R*, Zheng J*, Trajanoska K*, Soerensen M*, Forgetta V, Castillo-Fernandez JE, Frost M, Spector TD, Christensen K, Christiansen L, Rivadeneira F, Tobias JH, Evans DM, Kiel DP, Hsu Y-H, Richards JB, Bell JT. Journal of Bone and Mineral Research (2017).

• Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, Thalamuthu A, Mangino M, Liu J, Demirkan A, Lek M, Xu L, Wang G, Oldmeadow C, Gaulton KJ, Lotta LA, Miyamoto-Mikami E, Rivas MA, White T, Loh P-R, Aadahl M, Amin N, Attia JR, Austin K, Benyamin B, Brage S, Cheng Y-C, Cieszczyk P, Derave W, Eriksson K-F, Eynon N, Linneberg A, Lucia A, Massidda M, Mitchell BD, Miyachi M, Murakami H, Padmanabhan S, Pandey A, Papadimitriou I, Rajpal D, Sale C, Schnurr TM, Sessa F, Shrine N, Tobin MD, Varley I, Wain LV, Wray NR, Lindgren CM, MacArthur DG, Waterworth D, McCarthy MI, Pedersen O, Khaw K-T, Kiel DP, GEFOS Anytype of Fracture Consortium, Pitsiladis Y, Fuku N, Franks PW, North KN, van Duijn CM, Mather KA, Hansen T, Hansson O, Spector T, Murabito JM, Richards JB, Rivadeneira F, Langenberg C, Perry JRB, Wareham NJ, Scott RA. Nature Communications (2017).

• A Mendelian randomization study of the effect of type-2 diabetes on bone mineral density. Ahmad OS, Leong A, Miller JA, Morris JA, Forgetta V, Mujamammi M, Richards, JB. Journal of Bone and Mineral Research (2017).

• Genetically decreased vitamin D and risk of Alzheimer disease. Mokry LE, Ross S, Morris JA, Manousaki D, Forgetta V, Richards JB. Neurology (2016).

• Using epigenomic data to inform genome-wide association studies of bone mineral density. Morris JA. Annals of Translational Medicine (2016).

• Genetic drivers of epigenetic and transcriptional variation in human immune cells. Chen L, Ge B, Casale FP, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yan Y, Kundu K, Ecker S, Datta A, Richardson D, Burden F, Mead D, Mann AL, Fernandez JM, Rowlston S, Wilder SP, Farrow S, Shao X, Lambourne JJ, Redensek A, Albers CA, Amstislavskiy V, Ashford S, Berentsen K, Bomba L, Bourque G, Bujold D, Busche S, Caron M, Chen SH, Cheung W, Delaneau O, Dermitzakis ET, Elding H, Colgiu I, Bagger FO, Flicek P, Habibi E, Iotchkova V, Janssen-Megens E, Kim B, Lehrach H, Lowy E, Mandoli A, Matarese F, Maurano MT, Morris JA, Pancaldi V, Pourfarzad F, Rehnstrom K, Rendon A, Risch T, Sharifi N, Simon MM, Sultan M, Valencia A, Walter K, Wang SY, Frontini M, Antonarakis SE, Clarke L, Yaspo ML, Beck S, Guigo R, Rico D, Martens JH, Ouwehand WH, Kuijpers TW, Paul DS, Stunnenberg HG, Stegle O, Downes K, Pastinen T, Soranzo N. Cell (2016).

• Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min J, Chen L, Astle W, Cocca M, Deelen P, Elding H, Farmaki A-E, Franklin C, Gaunt T, Hofman A, Jiang T, Kleber M, Luan J, Malerba G, Matchan A, Mead D, Memari Y, Ntalla I, Panoutsopoulou K, Pazoki R, Perry J, Rivadeneira F, Shin S-Y, Southam L, Traglia M, van Dijk D, van Leeuwen E, Zaza G, Zhang W, Amin N, Butterworth A, Chambers J, Dedoussis G, Dehghan A, Franco O, Franke L, Frontini M, Gambaro G, Gasparini P, Isaacs A , Kooner J, Kooperberg C, Langenberg C, März W, Scott R, Swertz M, Toniolo D, Uitterlinden A, van Duijn C, Zeggini E, Maurano M, Lachance G, Timpson N, Frånberg M, Sabater-Lleal M, Sennblad B, Hamsten A, Watkins H, Reiner A, Auer P, Soranzo N. Nature Genetics (2016).

• A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease. Ahmad OS, Morris JA, Mujammami M, Forgetta V, Leong A, Li R, Turgeon M, Greenwood CMT, Thanassoulis G, Meigs JB, Sladek R, Richards JB. Nature Communications (2015).